Featured Interview


My guest is Chrystal from L.A.. She is just one of many positive diabetics making a huge difference in the diabetes community. She is a chemist, and diabetic activist. After Chrystal's diagnosis of type 2 diabetes in November 2007, she created SexyDiabetic.com; and donates a good portion of her time connecting and sharing experiences, both inside and outside the online diabetic communities.


Chrystal has shared with us her personal experiences living with diabetes; her role in the diabetic community; some of her current diabetic project she's working on during black history month.


We talked about some of the struggles we we face, getting the African American communities and all other people of color educated on the dangers of diabetes; as well as the fears and discrimination that still exist for diabetics today.


Click here to listen with your default media player

Richard A. Vaugn


For 2012 I thought it would be wonderful to start the year off with a positive interview!


My guest is Richard A Vaughn. He has written an awesome book called "Beating The Odds - 64 years of Diabetes Health". In this book, he takes us on a journey through his diabetic life.


From the moment he was diagnosed with type 1 at the age of 6, all the way up through completing his masters degree, @ a time when people thought diabetics shouldn't go to college (because diabetes was considered a disability then).


Richard also talks about his wonderful family and grand children, in addition to participating in the Joslin Medalist Study, funded by the JDRF & National Institute of health..


Richard is definitely an inspiration to us all. He has showed us insulin dependent people, how to live healthy emotionally & physically by example, with either no, or the least amount of complications possible; coming from a time when life expectancy for a diabetic was no later than 40 years old.


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Click here to listen with your default audio player!


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You can purchase Richard's book by clicking on the graphic of his book below.




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Diabetic PlayList

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What's in your headphones? We all know how important exercise is to any diabetic, however, the music you exercise to is also just as important too! Music can make the difference between a 3 minute workout, and a 30 minute workout. Personally, I am an oldies guy, and my musical tastes are pretty eclectic and diverse. The above playlist consist of music I am listening to on my Anddroid when I exercise or power-walk. As my mood changes, so shall the playlist.
TuDiabetes
Diabetic Connect
I'm a member of Diabetic Connect
Dear Janis
I'm a member of Dear Janis
Diabetes Stats



Socks4Life is working hard to inform their customers about diabetes.
Click here to read article


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Genetic prediction of type 2 diabetes in the Botnia study

Type 2 diabetes has been loosely defined as “adult onset” diabetes, but as diabetes becomes more common, cases are being diagnosed in younger people and children. In determining the risk of developing diabetes, environmental factors, such as food intake and exercise, are known to have an important role; most people with type 2 diabetes are either overweight or obese. Inherited factors are also important, but the genes involved remain poorly defined. In rare forms of diabetes, mutations of one gene can result in disease, whereas in type 2 diabetes, many genes are thought to be involved. One difficulty in understanding the genetic role is that genes associated with diabetes might show only a subtle variation in their sequence, and these variations may be extremely common. Hence, it can be very hard to link such common gene variations, known as single nucleotide polymorphisms (SNPs), with increased risk of developing diabetes.

One method of finding these diabetes genes is by whole-genome linkage studies in which associations between parts of the genome and risk of developing diabetes are looked for. Studies so far have identified several candidate genes associated with type 2 diabetes, although many results have been difficult to replicate. The list of genes for which there is good evidence from meta-analyses includes genes encoding for PPARG, calpain 10, Kir 6.2, and insulin receptor substrate-1 (IRS1).

These genes have a variety of effects; PPARG P12A polymorphism is associated with enhanced insulin sensitivity and protects against type 2 diabetes. Two SNPs in the gene encoding for cystein protease calpain 10 (CAPN10) confer increased susceptibility to insulin resistance and type 2 diabetes. Kir 6.2 is involved in glucose-stimulated insulin secretion in pancreatic cells. And carriers of a polymorphism in the IRS1 gene have been shown to have reduced islet insulin content in pancreatic islets.

In this issue of PLoS Medicine, Valeriya Lyssenko and colleagues from Lund University sought to consolidate previous work by studying the predictive value of these variants for type 2 diabetes side by side in the largest study of its kind to date. They investigated the effect of these gene variants in 2,293 nondiabetic people aged 18–70 years old in western Finland—the Botnia study—over a median of six, range 2–12, years. In addition, they also studied the uncoupling protein 2 gene (UCP2)—a polymorphism in the promoter of this gene (UCP2 −866G>A) (rs659366) has been associated in some, but not all, studies with increased risk of type 2 diabetes and impaired insulin secretion.

The study took place from 1990 to 2002, and enrolled patients from five health centers in western Finland who were asked to have health checks every two to three years. Six percent (132) of people developed type 2 diabetes. The key finding was that variants in the PPARG and CAPN10 genes increased future risk for type 2 diabetes, particularly in individuals with other risk factors. In individuals with a high risk of developing diabetes—with a fasting plasma glucose (FPG) of 5.6 millimoles per liter and body mass index (BMI) of 30 kilograms per square meter—the hazard ratio increased to 21.2 for the combination of the PPARG PP and CAPN10 SNP43/44 GG/TT genotypes compared with those with low-risk genotypes with normal FPG and BMI less than 30 kilograms per square meter.

The researchers found that replacing the family history with the PPARG and CAPN10 variants in a predictive model (particularly in combination) gave almost the same strong prediction of subsequent type 2 diabetes. These genotypes also influenced the relationship between BMI and FPG, that is, in carriers of risk genotypes, there was a steeper increase in FPG for any given BMI.

The authors argue that the comparison of all the key gene variants side by side in one large study adds substantially to previous papers that have examined the effect of single gene variants on the risk of conversion to type 2 diabetes in interventional trials.

However, it is important to understand the effect of these variants on the risk of disease in a large, prospective observational study before studying additive or synergistic effects with interactions such as lifestyle changes, they said. One of the problems of other studies has been that results have been different between different subgroups.

Although this study has limited power, as the largest of its kind it suggests that genetic variants in candidate genes can predict future type 2 diabetes, particularly in association with conventional risk factors such as obesity and abnormal glucose tolerance. With accumulating data from prospective studies, it should be possible to define whether there will be a future role for genetic prediction of type 2 diabetes or whether these variants will influence response to prevention or treatment.

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